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E621 is the food additive code for monosodium glutamate, a sodium salt of glutamic acid, an amino acid that naturally occurs in various foods, including tomatoes, cheeses, and mushrooms. MSG was first isolated in 1908 by Japanese chemist Kikunae Ikeda, who discovered its ability to impart a savory flavor, which he named umami, to dishes. This prompted its use as a seasoning, especially in Asian cuisine, leading to its commercialization in the form of flavor enhancers.