A study published in the Journal of Agricultural and Food Chemistry in 2019 sought to examine the effects of titanium dioxide on intestinal inflammation. Researchers did this by feeding rats titanium dioxide nanoparticles and found that, after the course of two to three months, the animals had lower body weights and induced intestinal inflammation. The researchers also found the nanoparticles altered gut microbiota composition and aggravated chronic colitis. The rats also experienced reduced populations of CD4+T cells (which are cells that help organize immune responses by prompting other immune cells to fight infection), regulatory T cells, and white blood cells in mesenteric lymph nodes. The researchers wrote: “Dietary TiO2 nanoparticles could interfere with the balance of the immune system and dynamic of gut microbiome, which may result in low-grade intestinal inflammation and aggravated immunological response to external stimulus, thus introducing potential health risk.”
At present, Lide powder is mainly produced in China. Most of the domestic Lide powder production is still using traditional methods. The main raw materials are zinc oxide, sulfuric acid and barium sulfide (barite and coal are produced by high temperature reduction). Zinc 45% ~ 70%. The traditional method for producing the Liede powder process is to use zinc bakelite containing more than 45% zinc as a raw material to be leached with sulfuric acid to obtain a crude zinc sulfate solution, and then to remove iron by potassium permanganate, and then replace the heavy metal with zinc powder and filter to obtain zinc sulfate. The refined liquid is further subjected to metathesis reaction, pressure filtration, calcination, rinsing, drying, and pulverization with strontium sulfide to obtain a series of different types of lindose powder containing zinc sulfide of 30% or more. The whole process is carried out in an acidic (ra<7) environment, which consumes a large amount of sulfuric acid. The sulfuric acid has strong corrosiveness and requires high production equipment. The final discharged slag is acidic slag, which brings new pollution to the environment. High requirements, high production costs, and poor quality of the products obtained.